北京优尼康生物科技有限公司

色素上皮衍生因子（PEDF）是一种多能神经营养因子，在中枢神经系统和视网膜中均具有很强的活性。到目前为止，PEDF是在哺乳动物的眼腔中所发现的最强的抗血管生长因子。有趣的是，最近的研究显示眼部PEDF水平的降低与视网膜病变和其他神经视网膜营养不良性疾病存在相关性。并且，PEDF表现出来的神经营养特性和抗血管生成的特性，提示这种蛋白在控制与生长相关的新血管生成中具有潜在的治疗价值。为了便于研究这一重要的丝氨酸蛋白酶抑制蛋白超家族的成员-PEDF，我们研发了一种敏感的PEDF ELISA试剂盒，这种试剂盒通过使用多克隆抗体特异性的检测存在于人的玻璃体和其他组织中的天然PEDF蛋白。与其他的商业性的PEDF ELISA试剂盒相比较，我们的PEDF ELISA试剂盒的敏感性几乎是其他同类产品的50倍。事实上，我们的研究起初即以接近于其他PEDF ELISA试剂盒产品检测限的PEDF浓度进行实验的。如果您的研究需要对PEDF进行定量，我们的PEDF ELISA试剂盒将会是您的选择对象。

Pigment epithelium-derived factor (PEDF) is a multipotent neurotrophic factor with potent activity both in the central nervous system and in the retina. To date, PEDF is the most potent angiogenic inhibitor found in the mammalian ocular compartment. Interestingly, recent studies have shown that decreased ocular levels of PEDF are associated with diabetic retinopathy and other neuroretinal dystrophic diseases. In addition, the neurotropic and anti-angiogenic properties of PEDF suggest this protein is of potential therapeutic value for control of neovascularization associated with tumor growth.   To facilitate research on this important member of the serpin protein superfamily, we have developed a sensitive PEDF ELISA using polyclonal antibodies that specifically detects native PEDF protein in human vitreous and other tissues.   Compared to other commercially-available PEDF ELISA kits, our PEDF ELISA is nearly 50-times more sensitive than the competitor's product. In fact, our assay starts at PEDF concentrations that are near the limit-of-detection for other PEDF ELISAs (see above).  If you need to quantify PEDF levels in your studies, our PEDF ELISA kit is the best solution to consider!